RESEARCH ARTICLE
Nobel Med 2013; 9(3): 110-115
THE EVALUATION OF RELATIONSHIP BETWEEN PLASMA ASYMMETRIC DIMETHYLARGININE (ADMA) AND AORTIC STIFFNESS IN PATIENTS WITH SYSTEMIC SCLEROSIS
Zuhal Arıtürk, Şevin Dağ, M. Ali Elbey, Hasan Kaya, Faruk Ertaş, Mehtap Bozkurt, Remzi Çevik, Derya Uçmak
ABSTRACT
Objective: Endothelial dysfunction and vasculopathy are crucial pathogenic factors in systemic sclerosis. Increased concentrations of plasma asymmetric dimethylarginine (ADMA) may also contribute to endothelial dysfunction in patients with systemic sclerosis. We evaluated the relationship between ADMA and aortic elastic properties in patients with systemic sclerosis.
Material and Method: Plasma ADMA levels were measured in 30 patients with systemic sclerosis (28 females, mean age 40.7±11.6) and 30 healthy subjects (27 females, mean age 40.6±13). Aortic stiffness was determined with echocardiography.
Results: In patients with systemic sclerosis, the mean value of ADMA was 0.53±0.13µmol/l compared with 0.46±0.15 µmol/l for control group. Systolic blood pressure, pulse pressure and aortic ‘strain’ were found to be higher in patients with systemic sclerosis (p=0.027, p=0.048, p=0.037, respectively), diyastolic blood pressure and aortic distensibility was found lower in systemic sclerosis (p=0.039, p=0.045, respectively). There was no significant correlations between ADMA and aortic ‘strain’.
Conclusion: ADMA serum levels were increased in patients with systemic sclerosis, but no significant correlation was found between ADMA and aort’s elastic structure (aortic ‘strain’, distensibility, and aortic stiffness index).
Keywords
Systemic sclerosis Asymmetric dimethylarginine Aorta
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Pubmed Style
Zuhal Arıtürk, Şevin Dağ, M. Ali Elbey, Hasan Kaya, Faruk Ertaş, Mehtap Bozkurt, Remzi Çevik, Derya Uçmak. [SİSTEMİK SKLEROZU OLAN HASTALARDA AORTUN ELASTİK YAPISI İLE PLAZMA ASİMETRİK DİMETİLARGİNİN (ADMA) ARASINDAKİ İLİŞKİNİN DEĞERLENDİRİLMESİ]. Nobel Med 2013; 9(3): 110-115, Turkish. -
Web Style
Zuhal Arıtürk, Şevin Dağ, M. Ali Elbey, Hasan Kaya, Faruk Ertaş, Mehtap Bozkurt, Remzi Çevik, Derya Uçmak. [SİSTEMİK SKLEROZU OLAN HASTALARDA AORTUN ELASTİK YAPISI İLE PLAZMA ASİMETRİK DİMETİLARGİNİN (ADMA) ARASINDAKİ İLİŞKİNİN DEĞERLENDİRİLMESİ]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], Turkish. -
AMA (American Medical Association) Style
Zuhal Arıtürk, Şevin Dağ, M. Ali Elbey, Hasan Kaya, Faruk Ertaş, Mehtap Bozkurt, Remzi Çevik, Derya Uçmak. [SİSTEMİK SKLEROZU OLAN HASTALARDA AORTUN ELASTİK YAPISI İLE PLAZMA ASİMETRİK DİMETİLARGİNİN (ADMA) ARASINDAKİ İLİŞKİNİN DEĞERLENDİRİLMESİ]. Nobel Med 2013; 9(3): 110-115, Turkish. -
Vancouver/ICMJE Style
Zuhal Arıtürk, Şevin Dağ, M. Ali Elbey, Hasan Kaya, Faruk Ertaş, Mehtap Bozkurt, Remzi Çevik, Derya Uçmak. [SİSTEMİK SKLEROZU OLAN HASTALARDA AORTUN ELASTİK YAPISI İLE PLAZMA ASİMETRİK DİMETİLARGİNİN (ADMA) ARASINDAKİ İLİŞKİNİN DEĞERLENDİRİLMESİ]. Nobel Med (2013); 9(3): 110-115, [cited Mayıs 24, 2021], Turkish. -
Harvard Style
Zuhal Arıtürk, Şevin Dağ, M. Ali Elbey, Hasan Kaya, Faruk Ertaş, Mehtap Bozkurt, Remzi Çevik, Derya Uçmak. (2013) [SİSTEMİK SKLEROZU OLAN HASTALARDA AORTUN ELASTİK YAPISI İLE PLAZMA ASİMETRİK DİMETİLARGİNİN (ADMA) ARASINDAKİ İLİŞKİNİN DEĞERLENDİRİLMESİ]. Nobel Med, 9(3): 110-115, Turkish.
